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This pre-conceptual design of the MSR (Molten Salt Reactor) reactor core refers to the ship as a platform to be used in making the land-based MSR reactor laboratory. The design is carried out based on specifications stipulated on the user requirements. In this design, limits are used, such as the minimum thermal power of 16 MW, the maximum core volume of 3.4 m3, and the maximum power density of 14 MW/m3. The designed thermal power levels include 20 MWt, 30 MWt, 40 MWt and 50 MWt. The design is carried out by using the WIMSD-5B and CITATION analytic tools. The advantage of the designed core is its flexibility to be used with various types of salt fuel. The molten salt fuels are NaF-BeF2-UF4, NaF-BeF2-ThF4-U(233)F4 and NaF-BeF2-ThF4-U(235)F4, with the low uranium enrichment. The calculation results show that the composition (% mole) for the three fuels types are 76-21-3, 76-12-11,35-0.65 and 67.6-12-14-6.4, respectively. Based on the design results, if the maximum terrace requirement of 3.4 m3 is used, there are not many reactor power options, because the heat density is greater than 14 MWt/m3. Therefore, the optimization is carried out based on the maximum power density of 14 MW/m3. The optimization resulted in 19 alternative cores with the power of 20 MWt (7 cores), 30 MWt (7 cores), 40 MWt (4 cores) and 50 MWt (1 core). We proposed the core with 20 MWt for the ship, while for the land-based MSR laboratory the acceptable power is 40 MWt that can be produced by 2 core units of 20 MWt.